PDF DatasheetHuman Anti-MUC5AC Antibody Product Attributes
MUC5AC Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in MUC5AC antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. More moderate antibody staining intensity was present in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. Low, but measureable presence of MUC5AC could be seen in. We were unable to detect MUC5AC in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| MUC5AC General Information | |
|---|---|
| Alternate Names | |
| Mucin 5AC, Muc5AC, MUC5AC | |
| Molecular Weight | |
| >1,000kDa | |
| Chromosomal Location | |
| 11p15.5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MUC5AC |
| Entrez Gene ID | 4586 |
| Ensemble Gene ID | ENSG00000215182, ENSG00000283158 |
| RefSeq Protein Accession(s) | NP_001291288 |
| RefSeq mRNA Accession(s) | NM_017511, NM_001304359 |
| RefSeq Genomic Accession(s) | NW_015148966, NC_000011, NC_018922 |
| UniProt ID(s) | P98088, Q7M4S5 |
| UniGene ID(s) | P98088, Q7M4S5 |
| HGNC ID(s) | 7515 |
| Cosmic ID(s) | MUC5AC |
| KEGG Gene ID(s) | hsa:4586 |
| PharmGKB ID(s) | PA31321 |
| General Description of MUC5AC. | |
| Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells, can be divided into two families; secretory mucins, membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric, tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma, pre-cancerous changes vs. normal pancreas. | |
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