Human and Rat Anti-Ornithine Decarboxylase-1 Antibody Product Attributes
Ornithine Decarboxylase-1 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-ODC1 antibody staining is expected to be primarily localized to the cytosol and plasma membrane.
Observed Antibody Staining Data By Tissue Type:
Variations in Ornithine Decarboxylase-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hepatocytes in liver, exocrine glandular cells in the pancreas, decidual cells in the placenta, glandular cells in the salivary gland and small intestine and Leydig cells in the testis. More moderate antibody staining intensity was present in hepatocytes in liver, exocrine glandular cells in the pancreas, decidual cells in the placenta, glandular cells in the salivary gland and small intestine and Leydig cells in the testis. Low, but measureable presence of Ornithine Decarboxylase-1 could be seen inglandular cells in the appendix, hematopoietic cells in the bone marrow, adipocytes in breast, glandular cells in the breast, respiratory epithelial cells in the bronchus, glial cells in the caudate nucleus, neuronal cells in the caudate nucleus, cells in the granular layer in cerebellum, cells in the molecular layer in cerebellum, Purkinje cells in the cerebellum, endothelial cells in the cerebral cortex, glial cells in the cerebral cortex, neuronal cells in the cerebral cortex, neuropil in cerebral cortex, endothelial cells in the colon, cells in the endometrial stroma in endometrium, squamous epithelial cells in the esophagus, glial cells in the hippocampus, neuronal cells in the hippocampus, pneumocytes in lung, non-germinal center cells in the lymph node, squamous epithelial cells in the oral mucosa, glandular cells in the parathyroid gland and rectum, melanocytes in skin, epidermal cells in the skin, adipocytes in mesenchymal tissue, chondrocytes in mesenchymal tissue, fibroblasts in mesenchymal tissue, peripheral nerve in mesenchymal tissue, cells in the seminiferous ducts in testis, germinal center cells in the tonsil, non-germinal center cells in the tonsil, urothelial cells in the urinary bladder and squamous epithelial cells in the vagina. We were unable to detect Ornithine Decarboxylase-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Ornithine Decarboxylase-1 expression as measured by anti-Ornithine Decarboxylase-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal Intensity | ++ | – | ++ | ++ | ++ | – | – | ++ | + | – | – | ++ | + | +++ | + | – | + | – | + | – |
ODC1 Variability | ++ | ++ | ++ | ++ | + | + | ++ | ++ | ++ | + | ++ | ++ | ++ | + | ++ | ++ | ++ | + | + | ++ |
Ornithine Decarboxylase-1 General Information | |
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Alternate Names | |
Ornithine decarboxylase, ODC1 | |
Molecular Weight | |
53kDa | |
Chromosomal Location | |
2p25.1 | |
Curated Database and Bioinformatic Data | |
Gene Symbol | ODC1 |
Entrez Gene ID | 4953 |
Ensemble Gene ID | ENSG00000115758 |
RefSeq Protein Accession(s) | NP_001274117, NP_001274118, NP_001274119, NP_002530 |
RefSeq mRNA Accession(s) | NM_001287189, NM_001287188, NM_002539 NM_001287190 |
RefSeq Genomic Accession(s) | NC_000002, NC_018913, NG_012105 |
UniProt ID(s) | B4DXF8, P11926 |
UniGene ID(s) | B4DXF8, P11926 |
HGNC ID(s) | 8109 |
Cosmic ID(s) | ODC1 |
KEGG Gene ID(s) | hsa:4953 |
PharmGKB ID(s) | PA31897 |
General Description of Ornithine Decarboxylase-1. | |
Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial, rate-limiting enzyme in the biosynthetic pathway of polyamines, is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens,, tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas, carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas, normal mucosa. |
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