PDF DatasheetHuman Anti-PAX8 Antibody Product Attributes
Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-PAX8 Antibody Clone: PAX8/1492
Clone PAX8/1492 Host and Isotype: Mouse IgG2a
Anti-Human PAX8 Positive Control Sample: Raji cells. Renal Cell Carcinoma (RCC)
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human PAX8 fragment (aa60-261)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
PAX8 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-PAX8 antibody staining is expected to be primarily localized to the nucleoplasm.
| PAX8 General Information | |
|---|---|
| Alternate Names | |
| Paired box gene 8, PAX8 | |
| Molecular Weight | |
| 62kDa | |
| Chromosomal Location | |
| 2q13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PAX8 |
| Entrez Gene ID | 7849 |
| Ensemble Gene ID | ENSG00000125618 |
| RefSeq Protein Accession(s) | NP_003457, NP_039246, XP_011510093, XP_011510096, XP_011510094, XP_011510095, XP_016860368, NP_039247, XP_011510092, NP_054698, XP_016860367 |
| RefSeq mRNA Accession(s) | NM_013951, XM_017004878, XM_011511790, XR_923021, XM_011511793, NM_013992 NM_013953, XM_011511791, XM_011511792, XM_017004879, XM_011511794, NM_003466, NM_013952 |
| RefSeq Genomic Accession(s) | NC_018913, NG_012384, NC_000002 |
| UniProt ID(s) | R9W7C9, A0A024R4X8, A0A024R531, A0A024R524, Q06710 |
| UniGene ID(s) | R9W7C9, A0A024R4X8, A0A024R531, A0A024R524, Q06710 |
| HGNC ID(s) | 8622 |
| Cosmic ID(s) | PAX8 |
| KEGG Gene ID(s) | hsa:7849 |
| PharmGKB ID(s) | PA32962 |
| General Description of PAX8. | |
| Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors. | |
Limitations and Warranty
enQuire Bio’s PAX8 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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