PDF DatasheetHuman Anti-PSAP Antibody Product Attributes
PSAP Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in PSAP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the prostate. More moderate antibody staining intensity was present in glandular cells in the prostate. Low, but measureable presence of PSAP could be seen in. We were unable to detect PSAP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of PSAP expression as measured by anti-PSAP antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | – | +++ | – | – | – | – | – | – |
| ACPP Variability | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + |
| PSAP General Information | |
|---|---|
| Alternate Names | |
| Prostatic acid phosphatase, PAP, prostatic specific acid phosphatase, PSAP | |
| Molecular Weight | |
| 52kDa | |
| Chromosomal Location | |
| 3q22.1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ACPP |
| Entrez Gene ID | 55 |
| Ensemble Gene ID | ENSG00000014257 |
| RefSeq Protein Accession(s) | XP_011511248, NP_001090, NP_001278966, XP_011511249, NP_001127666 |
| RefSeq mRNA Accession(s) | XM_011512946, NM_001134194, XM_011512947, NM_001292037 NM_001099 |
| RefSeq Genomic Accession(s) | NC_000003, NC_018914, NG_047032 |
| UniProt ID(s) | P15309 |
| UniGene ID(s) | P15309 |
| HGNC ID(s) | 125 |
| Cosmic ID(s) | ACPP |
| KEGG Gene ID(s) | hsa:55 |
| PharmGKB ID(s) | PA24449 |
| General Description of PSAP. | |
| Recognizes a protein of 52kDa, identified as prostate specific acid phosphatase (PSAP). This enzyme catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. PSAP is found in non-neoplastic adult and fetal prostatic glands, primary and metastatic prostatic carcinomas. It shows no staining in granulocytes, osteoclasts, parietal cells of the stomach, liver cells, renal cell or breast carcinomas. | |
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