PDF DatasheetAntibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Monoclonal
Anti-Synaptophysin Antibody Clone: SYP02
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Pancreas
Cellular Localization of Antibody SYP02 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with a synthetic peptide encoding a region near the C-terminal end of the synaptophysin protein.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Synaptophysin Information for Pathologists
Common Uses By Pathologists:
Common neuroendocrine marker (also chromogranin and CD56). Microscopic (histologic) images Images hosted on PathOut server:. Missing Image. Bladder: paraganglioma.
| Synaptophysin General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 33.8 kDa | |
| Chromosomal Location | |
| p11.23 [chr: X] [chr_start: 49187804] [chr_end: 49200259] [strand: -1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SYP |
| Entrez Gene ID | 6855 |
| RefSeq Protein Accession(s) | NP_003170 |
| RefSeq mRNA Accession(s) | ; NM_003179 |
| RefSeq Genomic Accession(s) | NC_000023; NG_012532 |
| UniProt ID(s) | P08247 |
| PharmGKB ID(s) | PA36288 |
| KEGG Gene ID(s) | hsa:6855 |
| Associated Diseases (KEGG IDs) | Mental retardation, X-linked 96 (MRX96) [MIM:300802]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:19377476}. The disease is caused by mutations affecting the gene represented in this entry. |
| General Description of Synaptophysin . | |
| This antibody is specific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types. | |
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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