PDF DatasheetHuman Anti-TDP2 / EAPII Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-TDP2 / EAPII Antibody Clone: TDP2/1258
Clone TDP2/1258 Host and Isotype: Mouse IgG2b kappa
Anti-Human TDP2 / EAPII Positive Control Sample: Jurkat cells. Lung, Duodenum or Small Intestinal Carcinoma.
Cellular Localization of Antibody Nuclear ;Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length TDP2 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
TDP2 / EAPII Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-TDP2 antibody staining is expected to be primarily localized to the nuclear bodies and nucleoplasm. There is variability in either the signal strength or the localization of signal in nuclear bodies from cell to cell.
| TDP2 / EAPII General Information | |
|---|---|
| Alternate Names | |
| 5′-Tyr-DNA phosphodiesterase, EAP2, EAPII, ETS1-associated protein 2, ETS1-associated protein II, TRAF and TNF receptor-associated protein, TTRAP, Tyr-DNA phosphodiesterase 2, Tyrosyl-DNA phosphodiesterase 2 (TDP2), anti-5′-Tyr-DNA phosphodiesterase antibody, anti-EAP2 antibody, anti-EAPII antibody, anti-ETS1-associated protein 2 antibody, anti-ETS1-associated protein II antibody, anti-TRAF and TNF receptor-associated protein antibody, anti-TTRAP antibody, anti-Tyr-DNA phosphodiesterase 2 antibody, anti-Tyrosyl-DNA phosphodiesterase 2 (TDP2) antibody | |
| Molecular Weight | |
| 41kDa | |
| Curated Database and Bioinformatic Data | |
| Entrez Gene ID | 51567 |
| Ensemble Gene ID | ENSG00000111802 |
| RefSeq Protein Accession(s) | NP_057698 |
| RefSeq mRNA Accession(s) | NM_016614, |
| RefSeq Genomic Accession(s) | NG_052787, NC_018917, NC_000006 |
| UniProt ID(s) | O95551 |
| UniGene ID(s) | O95551 |
| HGNC ID(s) | 17768 |
| Cosmic ID(s) | TDP2 |
| KEGG Gene ID(s) | hsa:51567 |
| PharmGKB ID(s) | PA165618310 |
| General Description of TDP2 / EAPII. | |
| This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5′-phosphodiester bond, giving rise to DNA with a free 5′ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5′-phosphoglycolates on protruding 5′ ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5′-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a ‘clean’ DSB with 5′-phosphate termini that are ready for ligation. Has also 3′-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation. | |
Limitations and Warranty
enQuire Bio’s TDP2 / EAPII Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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