Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor [P-GF.44C] Antibody (cGMP).

$ 158.00 – $ 818.00

SKU: QIVD194
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

PDF Datasheet

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.

Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.

Application Notes

Specification	Recommendation
Recommended Dilution (Conc)	1:25-1:75
Pretreatment	No Pretreatment Required
Incubation Parameters	30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal

Anti-Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor Antibody Clone: P-GF.44C

Host and Isotype: Mouse IgG1

Recommended Positive Control Sample: Breast carcinoma

Cellular Localization of Antibody P-GF.44C Staining: Cytoplasmic, Nuclear

Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN₃

Antibody Concentration: Lot specific. Plese contact tech support for data.

Immunogen: BALB/C mice were injected with a recombinant full length human thymidine phosphorylase (TP/PD-ECGF) protein.

Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor Information for Pathologists

Summary:

Thymidine Phosphorylase (also called Platelet-Derived Endothelial Cell Growth Factor or PD-ECG) regulates thymidine phosphorylation. It is involved in purine metabolism/pyrimidine metabolism and may play a role in bladder cancer, and mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

Common Uses By Pathologists:

Cancer patients often present with high levels of Thymidine Phosphorylase (TP). High intracellular staining for TP is indicative of tumor sensitivty to fluoropyrimidines such as apecitabine, Carmofur, Doxifluridine, or Fluorouracil.

Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor General Information
Alternate Names

Curated Database and Bioinformatic Data
UniProt ID(s)	P04085 and P01127
General Description of Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor .
This antibody is specific to a 55 kDa protein known as platelet-derived endothelial growth factor (PD-ECGF), or thymidine phosphorylase (TP). High levels of TP/PD-ECGF are observed in cancer patients. High intracellular levels of TP/PD-ECGF are associated with increased sensitivity to fluoropyrimidine chemotherapeutic agents.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

Size	0.1 ml, 0.5 ml, 1 ml
Tag	Unconjugated
Buffer and Stabilizer	PBS with 1% BSA and 0.05% NaN3
Product Type	Antibody
Host	Mouse
Isotype	IgG1
Applications	IHC
Species	Human
Format	Concentrate

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