PDF DatasheetHuman, Mouse, and Rat Anti-Thyroglobulin Antibody Product Attributes
Thyroglobulin Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Thyroglobulin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the thyroid gland. More moderate antibody staining intensity was present in glandular cells in the thyroid gland. Low, but measureable presence of Thyroglobulin could be seen in. We were unable to detect Thyroglobulin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Thyroglobulin expression as measured by anti-Thyroglobulin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | +++ | – |
| TG Variability | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + |
| Thyroglobulin General Information | |
|---|---|
| Alternate Names | |
| Thyroglobulin, Tg, Thyroid Hormone Precursor | |
| Molecular Weight | |
| 660kDa (Dimeric Form) | |
| Chromosomal Location | |
| 8q24.22 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TG |
| Entrez Gene ID | 7038 |
| Ensemble Gene ID | ENSG00000042832 |
| RefSeq Protein Accession(s) | XP_016869288, XP_006716685, XP_016869285, XP_005251097, XP_005251099, XP_016869283, XP_016869282, XP_016869289, XP_005251095, XP_016869284, XP_016869286, XP_016869287, NP_003226 |
| RefSeq mRNA Accession(s) | XM_017013794, XM_017013800, XM_006716622 NM_003235, XM_017013795, XM_017013798, XM_005251040, XM_017013799, XM_017013793, XM_005251038, XM_017013796, XM_017013797, XM_005251042 |
| RefSeq Genomic Accession(s) | NG_015832, NC_018919, NC_000008 |
| UniProt ID(s) | P01266 |
| UniGene ID(s) | P01266 |
| HGNC ID(s) | 11764 |
| Cosmic ID(s) | TG |
| KEGG Gene ID(s) | hsa:7038 |
| PharmGKB ID(s) | PA36479 |
| General Description of Thyroglobulin. | |
| MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by, processed within the thyroid gland to produce the hormone thyroxine, triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary, follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid, lung neoplasms. | |
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