PDF DatasheetHuman, Cow, Pig, Rabbit, and Mouse Anti-Transgelin Antibody Product Attributes
Transgelin Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-TAGLN antibody staining is expected to be primarily localized to the cytosol, microtubules and mitochondria. There is variability in either the signal strength or the localization of signal in cytosol from cell to cell.
Observed Antibody Staining Data By Tissue Type:
Variations in Transgelin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in myoepithelial cells in the breast and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in myoepithelial cells in the breast and smooth muscle cells in the smooth muscle. Low, but measureable presence of Transgelin could be seen inovarian stroma cells in the ovary. We were unable to detect Transgelin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| Transgelin General Information | |
|---|---|
| Alternate Names | |
| Transgelin, TAGLN | |
| Molecular Weight | |
| 22kDa | |
| Chromosomal Location | |
| 11q23.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TAGLN |
| Entrez Gene ID | 6876 |
| Ensemble Gene ID | ENSG00000149591 |
| RefSeq Protein Accession(s) | NP_001001522, NP_003177 |
| RefSeq mRNA Accession(s) | NM_003186, NM_001001522 |
| RefSeq Genomic Accession(s) | NC_000011, NC_018922 |
| UniProt ID(s) | Q5U0D2, Q01995 |
| UniGene ID(s) | Q5U0D2, Q01995 |
| HGNC ID(s) | 11553 |
| Cosmic ID(s) | TAGLN |
| KEGG Gene ID(s) | hsa:6876 |
| PharmGKB ID(s) | PA36324 |
| General Description of Transgelin. | |
| This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac, skeletal muscle, but is restricted during late fetal development, adulthood to all vascular, visceral smooth muscle cells, low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. | |
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