PDF DatasheetHuman Anti-TSH-Receptor, B-Chain Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-TSH-Receptor, B-Chain Antibody Clone: TSHRB/1405
Clone TSHRB/1405 Host and Isotype: Mouse IgG2a
Anti-Human TSH-Receptor, B-Chain Positive Control Sample: 293T Cells. Thyroid gland
Cellular Localization of Antibody Cell Surface ;Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human TSHR, B-Chain protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
TSH-Receptor, B-Chain Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of TSH-Receptor, B-Chain expression as measured by anti-TSH-Receptor, B-Chain antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | + | – | – | – | + | – | – | + | + | – | – | + | + | – | – | – | + | – | – | – |
| TSHR Variability | ++ | ++ | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ | + | ++ | ++ | ++ | + | ++ | ++ |
| TSH-Receptor, B-Chain General Information | |
|---|---|
| Alternate Names | |
| The thyrotropin receptor, TSH receptor, TSHR | |
| Molecular Weight | |
| 42kDa | |
| Chromosomal Location | |
| 14q31 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TSHR |
| Entrez Gene ID | 7253 |
| Ensemble Gene ID | ENSG00000165409 |
| RefSeq Protein Accession(s) | XP_005268096, XP_011535421, XP_006720308, NP_001136098, NP_001018046, NP_000360, XP_005268094 |
| RefSeq mRNA Accession(s) | XM_005268039, XM_011537119, NM_001018036, NM_001142626, XM_005268037, XM_006720245 NM_000369 |
| RefSeq Genomic Accession(s) | NG_009206, NC_018925, NC_000014 |
| UniProt ID(s) | A0A0A0MTJ0, P16473 |
| UniGene ID(s) | A0A0A0MTJ0, P16473 |
| HGNC ID(s) | 12373 |
| Cosmic ID(s) | TSHR |
| KEGG Gene ID(s) | hsa:7253 |
| PharmGKB ID(s) | PA37042 |
| General Description of TSH-Receptor, B-Chain. | |
| Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. | |
Limitations and Warranty
enQuire Bio’s TSH-Receptor, B-Chain Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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