.jpg "Anti-Aurora B Specificity Assay (Array)")
.jpg "Aurora B IHC human Prostate (AURKB 1593)")
%20SDS-PAGE%20Gel.jpg "Anti-Aurora B(AURKB 1593) SDS-PAGE Gel")
PDF DatasheetHuman Anti-Aurora B (Proliferation Marker) Antibody Product Attributes
Aurora B (Proliferation Marker) Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-AURKB antibody staining is expected to be primarily localized to the midbody and nucleoplasm. There is variability in either the signal strength or the localization of signal in midbody and nucleoplasm from cell to cell. Additionally, antibody labeling in the midbody is dependent upon phase within the cell cycle.
Observed Antibody Staining Data By Tissue Type:
Variations in Aurora B antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Aurora B could be seen in cells in the endometrial stroma in endometrium, cells in the white pulp in spleen, decidual cells in the placenta, epidermal cells in the skin, glandular cells in the adrenal gland, breast, colon, duodenum, endometrium, gallbladder, small intestine and stomach, glial cells in the cerebral cortex, keratinocytes in skin, macrophages in lung, myocytes in skeletal muscle, neuronal cells in the cerebral cortex, respiratory epithelial cells in the bronchus, smooth muscle cells in the smooth muscle, squamous epithelial cells in the esophagus and oral mucosa, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect Aurora B in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Aurora B expression as measured by anti-Aurora B antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | + | + | ++ | ++ | + | + | ++ | + | + | ++ | ++ | ++ | + | – | + | ++ | ++ | ++ | + | ++ |
| AURKB Variability | ++ | ++ | ++ | ++ | +++ | ++ | + | ++ | ++ | ++ | +++ | ++ | +++ | ++ | ++ | ++ | ++ | ++ | + | ++ |
| Aurora B (Proliferation Marker) General Information | |
|---|---|
| Alternate Names | |
| AIK2; AIM-1; ARK-2; AurB; AURKB; Aurora-1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48 (PPP1R48); Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5 | |
| Molecular Weight | |
| 39kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 9212 |
| Entrez Gene ID | AURKB |
| UniProt ID(s) | Q96GD4 |
| UniGene ID(s) | Hs442658 |
| COSMIC ID Link(s) | AURKB |
| KEGG Gene ID(s) | hsa:9212 |
| General Description of Aurora B (Proliferation Marker). | |
| Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. | |
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