PDF DatasheetHuman Anti-BOB.1 (B-Cell Marker) Antibody Product Attributes
Species: Human
Tested Applications: WB, IHC.
Clonality: Monoclonal
Anti-BOB.1 (B-Cell Marker) Antibody Clone: BOB1/2425
Clone BOB1/2425 Host and Isotype: Mouse IgG2b, kappa
Anti-Human BOB.1 (B-Cell Marker) Positive Control Sample: Raji and Ramos cells. Spleen or Tonsil.
Cellular Localization of Antibody BOB1/2425 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human BOB1 (POU2AF1) protein (apprx. aa 148-255) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
BOB.1 (B-Cell Marker) Previously Observed Antibody Staining Patterns
| BOB.1 (B-Cell Marker) General Information | |
|---|---|
| Alternate Names | |
| B cell Oct binding protein 1; B-cell-specific coactivator OBF-1; BOB-1; OBF1; OCA-B; OCAB; OCT-binding factor 1; POU domain class 2-associating factor 1; POU2AF1 | |
| Molecular Weight | |
| 35kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 5450 |
| Entrez Gene ID | POU2AF1 |
| UniProt ID(s) | Q16633 |
| UniGene ID(s) | Hs654525 |
| COSMIC ID Link(s) | POU2AF1 |
| KEGG Gene ID(s) | hsa:5450 |
| General Description of BOB.1 (B-Cell Marker). | |
| BOB.1 expression in a variety of established B-cell lines, representing different stages of B-cell development, has suggested a constitutive, B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma, because they are germinal center-derived, are consistently immuno-positive for BOB.1. Conversely, only some cases of classical Hodgkin lymphoma show BOB.1 immuno-reactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB.1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate immunoreactivity. | |
Limitations and Warranty
enQuire Bio’s product, BOB.1 (B-Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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