PDF DatasheetHuman Anti-CD163 (Monocyte & Macrophage Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-CD163 (Monocyte & Macrophage Marker) Antibody Clone: M130/1210
Clone M130/1210 Host and Isotype: Mouse IgG2b, kappa
Anti-Human CD163 (Monocyte & Macrophage Marker) Positive Control Sample: hPBL Cells. Skin, Lung, Placenta or Histiocytoma.
Cellular Localization of Antibody M130/1210 Staining: Cell Surface & Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human CD163 fragment (apprx. aa 43-196) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
CD163 (Monocyte & Macrophage Marker) Previously Observed Antibody Staining Patterns
| CD163 (Monocyte & Macrophage Marker) General Information | |
|---|---|
| Alternate Names | |
| CD163, CD163 antigen, Macrophage-associated antigen, M130, CD163 molecule, Hemoglobin scavenger receptor, MM130; Scavenger receptor cysteine rich type 1 protein M130 | |
| Molecular Weight | |
| 140kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 9332 |
| Entrez Gene ID | CD163 |
| UniProt ID(s) | Q86VB7 |
| UniGene ID(s) | Hs504641 |
| COSMIC ID Link(s) | CD163 |
| KEGG Gene ID(s) | hsa:9332 |
| General Description of CD163 (Monocyte & Macrophage Marker). | |
| This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. | |
Limitations and Warranty
enQuire Bio’s product, CD163 (Monocyte & Macrophage Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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