PDF DatasheetHuman Anti-CD68 (Macrophage Marker) Antibody Product Attributes
CD68 (Macrophage Marker) Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CD68 antibody staining is expected to be primarily localized to the vesicles and golgi apparatus.
Observed Antibody Staining Data By Tissue Type:
Variations in CD68 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen and macrophages in lung. More moderate antibody staining intensity was present in cells in the red pulp in spleen and macrophages in lung. Low, but measureable presence of CD68 could be seen inglial cells in the cerebral cortex. We were unable to detect CD68 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD68 (Macrophage Marker) General Information | |
|---|---|
| Alternate Names | |
| GP110, LAMP4, Microsialin, Macrosialin, SCARD1, Scavenger Receptor Class D Member-1 | |
| Molecular Weight | |
| 110kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 968 |
| Entrez Gene ID | CD68 |
| UniProt ID(s) | P34810 |
| UniGene ID(s) | Hs647419 |
| COSMIC ID Link(s) | CD68 |
| KEGG Gene ID(s) | hsa:968 |
| General Description of CD68 (Macrophage Marker). | |
| This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules. | |
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