Human Anti-Cyclin E (G1/S-Phase Cyclin) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Cyclin E (G1/S-Phase Cyclin) Antibody Clone: CCNE1/2460
Clone CCNE1/2460 Host and Isotype: Mouse IgG, kappa
Anti-Human Cyclin E (G1/S-Phase Cyclin) Positive Control Sample: HeLa Cells. Breast or Colon Carcinoma
Cellular Localization of Antibody CCNE1/2460 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Cyclin E (CCNE1) protein fragment (apprx. aa 10-176) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Cyclin E (G1/S-Phase Cyclin) Previously Observed Antibody Staining Patterns
Cyclin E (G1/S-Phase Cyclin) General Information | |
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Alternate Names | |
CCNE1; Cyclin E1; G1/S-specific cyclin-E1 | |
Molecular Weight | |
53kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 898 |
Entrez Gene ID | CCNE1 |
UniProt ID(s) | IDP24864 |
UniGene ID(s) | Hs244723 |
COSMIC ID Link(s) | CCNE1 |
KEGG Gene ID(s) | hsa:898 |
General Description of Cyclin E (G1/S-Phase Cyclin). | |
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. |
Limitations and Warranty
enQuire Bio’s product, Cyclin E (G1/S-Phase Cyclin) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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