Human Anti-DNMT3A / DNA Methyltransferase 3 Alpha Antibody Product Attributes
Species: Human
Tested Applications: IP, WB, IHC.
Clonality: Monoclonal
Anti-DNMT3A / DNA Methyltransferase 3 Alpha Antibody Clone: PCRP-DNMT3A-1E2
Clone PCRP-DNMT3A-1E2 Host and Isotype: Mouse IgG1
Anti-Human DNMT3A / DNA Methyltransferase 3 Alpha Positive Control Sample: HeLa cells orPlacenta
Cellular Localization of Antibody PCRP-DNMT3A-1E2 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human DNMT3A protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
DNMT3A / DNA Methyltransferase 3 Alpha Previously Observed Antibody Staining Patterns
DNMT3A / DNA Methyltransferase 3 Alpha General Information | |
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Alternate Names | |
DNA methyltransferase 3 alpha; DNA methyltransferase HsaIIIA; DNAMTaseHsaIIIA; DNMT; DNMT3A2; M.HsaIIIA; MCMT; TBRS | |
Molecular Weight | |
102kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 1788 |
Entrez Gene ID | DNMT3A |
UniProt ID(s) | Q16655 |
UniGene ID(s) | Hs154069 |
COSMIC ID Link(s) | DNMT3A |
KEGG Gene ID(s) | hsa:1788 |
General Description of DNMT3A / DNA Methyltransferase 3 Alpha. | |
The specificity of this monoclonal antibody to its intended target was validated by HuProtTMArray, containing more than 19,000, full-length human proteins.DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated ‘Lys-36’ of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Sadenosyl-L-methionin |
Limitations and Warranty
enQuire Bio’s product, DNMT3A / DNA Methyltransferase 3 Alpha MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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