PDF DatasheetHuman Anti-Emerin (Papillary Thyroid Carcinoma and EDMD Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Emerin (Papillary Thyroid Carcinoma and EDMD Marker) Antibody Clone: EMD/2168
Clone EMD/2168 Host and Isotype: Mouse IgG2b, kappa
Anti-Human Emerin (Papillary Thyroid Carcinoma and EDMD Marker) Positive Control Sample: K-562, HeLa or Jurkat cells. Kidney or Skin
Cellular Localization of Antibody EMD/2168 Staining: Nuclear Membrane
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Emerin protein fragment (apprx. aa 56-167) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Emerin (Papillary Thyroid Carcinoma and EDMD Marker) Previously Observed Antibody Staining Patterns
| Emerin (Papillary Thyroid Carcinoma and EDMD Marker) General Information | |
|---|---|
| Alternate Names | |
| EMD; Emerin; Emery Dreifuss muscular dystrophy (EDMD); STA | |
| Molecular Weight | |
| 37kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 2010 |
| Entrez Gene ID | EMD |
| UniProt ID(s) | P50402 |
| UniGene ID(s) | Hs522823 |
| COSMIC ID Link(s) | EMD |
| KEGG Gene ID(s) | hsa:2010 |
| General Description of Emerin (Papillary Thyroid Carcinoma and EDMD Marker). | |
| Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma. | |
Limitations and Warranty
enQuire Bio’s product, Emerin (Papillary Thyroid Carcinoma and EDMD Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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