Human Anti-GAD2 / GAD65 (GABAergic Neuronal Marker) Antibody Product Attributes
Species: Human
Tested Applications: ELISA, WB, IHC.
Clonality: Monoclonal
Anti-GAD2 / GAD65 (GABAergic Neuronal Marker) Antibody Clone: GAD2/1960
Clone GAD2/1960 Host and Isotype: Mouse IgG2b, kappa
Anti-Human GAD2 / GAD65 (GABAergic Neuronal Marker) Positive Control Sample: Pancreas or Brain.
Cellular Localization of Antibody GAD2/1960 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human GAD2 (GAD65) protein fragment (apprx. aa 6-99) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
GAD2 / GAD65 (GABAergic Neuronal Marker) Previously Observed Antibody Staining Patterns
GAD2 / GAD65 (GABAergic Neuronal Marker) General Information | |
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Alternate Names | |
DCE2; GAD2; Glutamic Acid Decarboxylase 2 (Pancreas); Glutamic Acid Decarboxylase 2 (Pancreatic Islets and Brain 65kDa); Glutamic Acid Decarboxylase 65 (GAD65) | |
Molecular Weight | |
65kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 2572 |
Entrez Gene ID | GAD2 |
UniProt ID(s) | Q05329 |
UniGene ID(s) | Hs231829 |
COSMIC ID Link(s) | GAD2 |
KEGG Gene ID(s) | hsa:2572 |
General Description of GAD2 / GAD65 (GABAergic Neuronal Marker). | |
This MAb recognizes a protein of 65kDa, which is identified as glutamic acid decarboxylase 2 (GDA2). It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD s) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67). GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (γ-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes. |
Limitations and Warranty
enQuire Bio’s product, GAD2 / GAD65 (GABAergic Neuronal Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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