Formalin-fixed, paraffin-embedded human Skin stained with gp100 Mouse Monoclonal Antibody (PMEL/2037).

Analysis of Protein Array containing more than 19,000 full-length human proteins using PMEL/gp100 Mouse Monoclonal Antibody (PMEL/2037).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Ultraspecific Antibody
Tested against >20,000 Human Proteins

Name: gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Ultraspecific Antibody <p style="font-size:small">Tested against &gt;20,000 Human Proteins</p>
SKU: 6490-MSM7-P0
Availability: InStock

$ 199.00 – $ 429.00

SKU: 6490-MSM7
Species: Human
Tested Applications: IHC, ELISA
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

Size

Tag

Clear

SKU: 6490-MSM7-P0 Categories: Antibody, ELISA, Human, IgG1, IHC, kappa, Mouse, Not MS Validated, Ultraspecific Antibodies, Unconjugated Tag: gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker)

PDF Datasheet

Human Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody Product Attributes

Species: Human

Tested Applications: IHC, ELISA.

Clonality: Monoclonal

Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody Clone: PMEL/2037

Clone PMEL/2037 Host and Isotype: Mouse IgG1, kappa

Anti-Human gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Positive Control Sample: SK-MEL-28 cells or Melanoma

Cellular Localization of Antibody PMEL/2037 Staining: Cytoplasmic

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.

Antibody Concentration: 200 ug/ml

Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.

Immunogen: Recombinant human SILV protein fragment (apprx. aa 376-502) (Please call for additional information.)

Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Previously Observed Antibody Staining Patterns

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) General Information
Alternate Names
95kDa melanocyte-specific secreted glycoprotein, M-beta; Melanocyte lineage specific antigen GP100; Melanocyte protein Pmel 17; Melanoma associated ME20 antigen; Melanosomal matrix protein17; Premelanosome protein (PMEL17); Secreted melanoma-associated ME20 antigen; SILV; Silver homolog
Molecular Weight
90-100kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol	6490
Entrez Gene ID	SILV
UniProt ID(s)	P40967
UniGene ID(s)	Hs95972
COSMIC ID Link(s)	SILV
KEGG Gene ID(s)	hsa:6490
General Description of gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker).
Cytotoxic T lymphocytes (CTL s) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.

Limitations and Warranty

enQuire Bio’s product, gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

Size	20 ug, 100 ug
Tag	Unconjugated
Buffer and Stabilizer	10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Product Type	Antibody
Host	Mouse
Isotype	IgG1, kappa
Applications	ELISA
Species	Human
Mass Spec Validated?	Not MS Validated

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gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Ultraspecific Antibody Tested against >20,000 Human Proteins

Human Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody Product Attributes

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

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