Human Anti-GPN1 / XAB1 (DNA Repair & Protein Synthesis) Antibody Product Attributes
Species: Human
Tested Applications: ELISA, IHC.
Clonality: Monoclonal
Anti-GPN1 / XAB1 (DNA Repair & Protein Synthesis) Antibody Clone: GPN1/2350
Clone GPN1/2350 Host and Isotype: Mouse IgG1, kappa
Anti-Human GPN1 / XAB1 (DNA Repair & Protein Synthesis) Positive Control Sample: Pancreas, Testis, Thyroid or Bladder.
Cellular Localization of Antibody GPN1/2350 Staining: Cytoplasmic & Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human GPN1 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
GPN1 / XAB1 (DNA Repair & Protein Synthesis) Previously Observed Antibody Staining Patterns
GPN1 / XAB1 (DNA Repair & Protein Synthesis) General Information | |
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Alternate Names | |
ATP(GTP) binding protein (ATPBD1A); GPN-loop GTPase 1; GPN1; MBD2-interacting protein (MBDin); NTPBP; RNA polymerase II associated protein 4 (RPAP4); XPA-binding protein 1 (XAB1) GTPase | |
Molecular Weight | |
42kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 11321 |
Entrez Gene ID | GPN1 |
UniProt ID(s) | Q9HCN4 |
UniGene ID(s) | Hs18259 |
COSMIC ID Link(s) | GPN1 |
KEGG Gene ID(s) | hsa:11321 |
General Description of GPN1 / XAB1 (DNA Repair & Protein Synthesis). | |
GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity. |
Limitations and Warranty
enQuire Bio’s product, GPN1 / XAB1 (DNA Repair & Protein Synthesis) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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