PDF DatasheetHuman Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Antibody Clone: GZMB/2403
Clone GZMB/2403 Host and Isotype: Mouse IgG2b
Anti-Human Granzyme B (NK/T-Cell Lymphoma Marker) Positive Control Sample: A431 cells. Tonsil, Spleen or Hodgkin s Lymphoma
Cellular Localization of Antibody GZMB/2403 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human GZMB protein (apprx. aa 73-187) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Granzyme B (NK/T-Cell Lymphoma Marker) Previously Observed Antibody Staining Patterns
| Granzyme B (NK/T-Cell Lymphoma Marker) General Information | |
|---|---|
| Alternate Names | |
| Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Granzyme B; Granzyme-2; GRB; Gzmb; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E | |
| Molecular Weight | |
| 29-32kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 3002 |
| Entrez Gene ID | GZMB |
| UniProt ID(s) | P10144 |
| UniGene ID(s) | Hs1051 |
| COSMIC ID Link(s) | GZMB |
| KEGG Gene ID(s) | hsa:3002 |
| General Description of Granzyme B (NK/T-Cell Lymphoma Marker). | |
| Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface ‘nonself’ antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease. | |
Limitations and Warranty
enQuire Bio’s product, Granzyme B (NK/T-Cell Lymphoma Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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