Human Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Antibody Clone: IGHG4/2042R
Clone IGHG4/2042R Host and Isotype: Rabbit IgG
Anti-Human IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Positive Control Sample: Tonsil
Cellular Localization of Antibody IGHG4/2042R Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A column purification.
Immunogen: Recombinant full-length human IGHG4 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Previously Observed Antibody Staining Patterns
IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) General Information | |
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Alternate Names | |
Ig gamma 4 chain C region; IGHG4; Immunoglobulin heavy constant gamma 4 (G4m marker) | |
Molecular Weight | |
150kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 3503 |
Entrez Gene ID | IGHG4 |
UniProt ID(s) | P01861 |
UniGene ID(s) | Hs510635 |
COSMIC ID Link(s) | IGHG4 |
KEGG Gene ID(s) | hsa:3503 |
General Description of IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker). | |
The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lympho-plasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells. |
Limitations and Warranty
enQuire Bio’s product, IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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