PDF DatasheetHuman Anti-Ki-67 (Proliferating Cell Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Ki-67 (Proliferating Cell Marker) Antibody Clone: MKI67/2462
Clone MKI67/2462 Host and Isotype: Mouse IgG2b, kappa
Anti-Human Ki-67 (Proliferating Cell Marker) Positive Control Sample: Any actively proliferating cells. Skin, Tonsil or Lymph Node
Cellular Localization of Antibody MKI67/2462 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Ki67 protein fragment (apprx. aa 2293-2478) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Ki-67 (Proliferating Cell Marker) Previously Observed Antibody Staining Patterns
| Ki-67 (Proliferating Cell Marker) General Information | |
|---|---|
| Alternate Names | |
| KI-67; Ki67; KI-67 Antigen (KIA); MKI67; Proliferation related Ki-67 antigen | |
| Molecular Weight | |
| 345kDa and 395kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 4288 |
| Entrez Gene ID | MKI67 |
| UniProt ID(s) | P46013 |
| UniGene ID(s) | Hs689823 |
| COSMIC ID Link(s) | MKI67 |
| KEGG Gene ID(s) | hsa:4288 |
| General Description of Ki-67 (Proliferating Cell Marker). | |
| Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations. | |
Limitations and Warranty
enQuire Bio’s product, Ki-67 (Proliferating Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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