Human Anti-MSH6 (DNA Mismatch Repair Protein) Antibody Product Attributes
Species: Human
Tested Applications: ELISA, WB.
Clonality: Monoclonal
Anti-MSH6 (DNA Mismatch Repair Protein) Antibody Clone: MSH6/2111
Clone MSH6/2111 Host and Isotype: Mouse IgG2b, kappa
Anti-Human MSH6 (DNA Mismatch Repair Protein) Positive Control Sample: A431 or HeLa cells. Colon Carcinoma
Cellular Localization of Antibody MSH6/2111 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human MSH6 protein (apprx. aa 374-540) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
MSH6 (DNA Mismatch Repair Protein) Previously Observed Antibody Staining Patterns
MSH6 (DNA Mismatch Repair Protein) General Information | |
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Alternate Names | |
DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein | |
Molecular Weight | |
85kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 2956 |
Entrez Gene ID | MSH6 |
UniProt ID(s) | P52701 |
UniGene ID(s) | Hs445052 |
COSMIC ID Link(s) | MSH6 |
KEGG Gene ID(s) | hsa:2956 |
General Description of MSH6 (DNA Mismatch Repair Protein). | |
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. |
Limitations and Warranty
enQuire Bio’s product, MSH6 (DNA Mismatch Repair Protein) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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