PDF DatasheetHuman Anti-MTAP (Tumor Suppressor Marker) Antibody Product Attributes
Species: Human
Tested Applications: ELISA, WB, IHC.
Clonality: Monoclonal
Anti-MTAP (Tumor Suppressor Marker) Antibody Clone: MTAP/1813
Clone MTAP/1813 Host and Isotype: Mouse IgG2b, kappa
Anti-Human MTAP (Tumor Suppressor Marker) Positive Control Sample: HepG2, A431, HeLa or MCF-7 cells. Kidney
Cellular Localization of Antibody MTAP/1813 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human MTAP protein fragment (aa97-196) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
MTAP (Tumor Suppressor Marker) Previously Observed Antibody Staining Patterns
| MTAP (Tumor Suppressor Marker) General Information | |
|---|---|
| Alternate Names | |
| BDMF; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5”-thioadenosine phosphorylase | |
| Molecular Weight | |
| 31kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 4507 |
| Entrez Gene ID | MTAP |
| UniProt ID(s) | Q13126 |
| UniGene ID(s) | Hs193268 |
| COSMIC ID Link(s) | MTAP |
| KEGG Gene ID(s) | hsa:4507 |
| General Description of MTAP (Tumor Suppressor Marker). | |
| Recognizes a protein of 31kDa, which is identified as MTAP (5′-deoxy-5′-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway. | |
Limitations and Warranty
enQuire Bio’s product, MTAP (Tumor Suppressor Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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