Human Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Antibody Clone: NA24
Clone NA24 Host and Isotype: Mouse IgG1, kappa
Anti-Human Nucleophosmin (Acute Myeloid Leukemia Marker) Positive Control Sample: MCF-7, HeLa or A431 cells. Skin, Colon
Cellular Localization of Antibody NA24 Staining: Nuclear and Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: GST fusion protein containing the N-terminal part of nucleophosmin fused to 14 amino acid of ALK protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Nucleophosmin (Acute Myeloid Leukemia Marker) Previously Observed Antibody Staining Patterns
Nucleophosmin (Acute Myeloid Leukemia Marker) General Information | |
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Alternate Names | |
NO38; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; Nucleophosmin/nucleoplasmin family member 1; Numatrin | |
Molecular Weight | |
33kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 4869 |
Entrez Gene ID | NPM1 |
UniProt ID(s) | P06748 |
UniGene ID(s) | Hs557550 |
COSMIC ID Link(s) | NPM1 |
KEGG Gene ID(s) | hsa:4869 |
General Description of Nucleophosmin (Acute Myeloid Leukemia Marker). | |
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia. |
Limitations and Warranty
enQuire Bio’s product, Nucleophosmin (Acute Myeloid Leukemia Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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