Human Anti-OCT-2 (POU2F2) (B-Cell Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-OCT-2 (POU2F2) (B-Cell Marker) Antibody Clone: OCT2/2136
Clone OCT2/2136 Host and Isotype: Mouse IgG1, kappa
Anti-Human OCT-2 (POU2F2) (B-Cell Marker) Positive Control Sample: Raji or U-937 cells. Spleen or Tonsil.
Cellular Localization of Antibody OCT2/2136 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human OCT2 protein (apprx. aa 112-297) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
OCT-2 (POU2F2) (B-Cell Marker) Previously Observed Antibody Staining Patterns
OCT-2 (POU2F2) (B-Cell Marker) General Information | |
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Alternate Names | |
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Oct-2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; POU domain class 2 transcription factor 2; POU2F2 | |
Molecular Weight | |
60kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 5452 |
Entrez Gene ID | POU2F2 |
UniProt ID(s) | P09086 |
UniGene ID(s) | Hs147381 |
COSMIC ID Link(s) | POU2F2 |
KEGG Gene ID(s) | hsa:5452 |
General Description of OCT-2 (POU2F2) (B-Cell Marker). | |
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation. |
Limitations and Warranty
enQuire Bio’s product, OCT-2 (POU2F2) (B-Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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