Human Anti-OLIG2 (Marker of Glial Brain Tumors) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-OLIG2 (Marker of Glial Brain Tumors) Antibody Clone: OLIG2/2400
Clone OLIG2/2400 Host and Isotype: Mouse IgG1, kappa
Anti-Human OLIG2 (Marker of Glial Brain Tumors) Positive Control Sample: THP-1 cells. Astrocytoma
Cellular Localization of Antibody OLIG2/2400 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human OLIG2 protein (apprx. aa 1-141) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
OLIG2 (Marker of Glial Brain Tumors) Previously Observed Antibody Staining Patterns
OLIG2 (Marker of Glial Brain Tumors) General Information | |
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Alternate Names | |
Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); OLIG2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; Protein kinase C-binding protein 2 (PRKCBP2); RACK17 | |
Molecular Weight | |
30-40kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 10215 |
Entrez Gene ID | OLIG2 |
UniProt ID(s) | Q13516 |
UniGene ID(s) | Hs176977 |
COSMIC ID Link(s) | OLIG2 |
KEGG Gene ID(s) | hsa:10215 |
General Description of OLIG2 (Marker of Glial Brain Tumors). | |
Olig2, a basic helix-loop-helix transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Although more than half of glioblastomas are positive for Olig2, expression is very weak in terms of both percentage of labeled cells and intensity. No Olig2 expression has been found in the non-glial tumors including neuro-epithelial tumors, ependymomas, sub-ependymomas, medulloblastomas, and non-neuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid / rhabdoid tumor, and haemangioblastomas. Compared to the strong staining seen in glioma samples, a weak expression is observed in non-tumoral brain tissue (gliosis). |
Limitations and Warranty
enQuire Bio’s product, OLIG2 (Marker of Glial Brain Tumors) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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