Human Anti-Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Antibody Clone: PRF1/2468
Clone PRF1/2468 Host and Isotype: Mouse IgG2b, kappa
Anti-Human Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Positive Control Sample: HDLM-2 Cells. Spleen
Cellular Localization of Antibody PRF1/2468 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Perforin-1 protein fragment (apprx. aa 413-552) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Previously Observed Antibody Staining Patterns
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) General Information | |
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Alternate Names | |
Cytolysin; FLH2; HPLH2; Lymphocyte pore-forming protein; PRF1 (pore forming protein 1); Perforin-1; PFP; PGFL; PIGF; PIGF-2; PLGF | |
Molecular Weight | |
75kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 5551 |
Entrez Gene ID | PRF1 |
UniProt ID(s) | P14222 |
UniGene ID(s) | Hs2200 |
COSMIC ID Link(s) | PRF1 |
KEGG Gene ID(s) | hsa:5551 |
General Description of Perforin-1 (Pore Forming Protein) (Apoptosis Marker). | |
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells. |
Limitations and Warranty
enQuire Bio’s product, Perforin-1 (Pore Forming Protein) (Apoptosis Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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