PDF DatasheetHuman IL 23 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL 23 based upon sequence from Human
Host: QP10704 protein expressed in HEK 293.
Available Tags: Untagged
Protein Construction: A cDNA sequence encoding the sequence of IL 23 was constructred and used to recombinantly synthesize the protein.
Recommended Applications: Bioactive
Application Notes
Recommended Reconstitution Instructions: It is recommended to reconstitute the lyophilized IL23 in sterile 1xPBS containing 0.1% endotoxin-free recombinant HSA.
Bioactivity Data: The activity, as determined by the dose dependent secretion of IL-17 in response to IL-23 using murine splenocytes, the ED50 is 1.9ng/ml.
Monomer or Dimer: Dimer
Amino Acid Sequence: MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
Purity: Greater than 95.0% as determined by analysis by SDS-PAGE.
Endotoxin Levels: < 1.0 EU per ug protein as determined by the LAL method.
Buffer: IL-23 was lyophilized from a 0.1µm filtered solution (1.05 mg/ml) containing 1xPBS.
Storage Conditions: Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
Physical Appearance: IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder.
| Recombinant Human IL 23 General Information | |
|---|---|
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| Alternate Names | |
| Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40), NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF2, CLMF p40. | |
| Molecular Weight | |
| 20.7 kDa | |
| Chromosomal Location | |
| q13.3 on chromosome 12 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL23A |
| Entrez Gene ID | 51561 |
| UniProt ID(s) | Q9NPF7 |
| COSMIC ID Link(s) | IL23A |
| KEGG Gene ID(s) | hsa:51561 |
| General Description of Recombinant Human IL 23. | |
| Human IL-23 produced in HEK cells is a 55kDa heterodimeric protein composed of 2 disulfide-linked subunits – 19kDa (p19) and 43 kDa (p40). | |
Limitations and Performance Guarantee
enQuire Bio’s products are guaranteed and approved for RESEARCH USE ONLY or manufacturing purposes. This product may not be used as a pharmaceutical agent, or other product intended for human consumption without meeting additional regulatory requirements. This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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