PDF DatasheetHuman Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Antibody Product Attributes
Species: Human
Tested Applications: ELISA.
Clonality: Monoclonal
Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Antibody Clone: PCRP-STAT3-2F12
Clone PCRP-STAT3-2F12 Host and Isotype: Mouse IgG2a
Anti-Human STAT3 / Signal Transducer and Activator of Transcription 3 Positive Control Sample: A431 and Raji cells. Kidney, Brain or Heart
Cellular Localization of Antibody PCRP-STAT3-2F12 Staining: Cytoplasmic and Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human STAT3 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
STAT3 / Signal Transducer and Activator of Transcription 3 Previously Observed Antibody Staining Patterns
| STAT3 / Signal Transducer and Activator of Transcription 3 General Information | |
|---|---|
| Alternate Names | |
| APRF; HIES; ADMIO; ADMIO1 | |
| Molecular Weight | |
| 88kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 6774 |
| Entrez Gene ID | STAT3 |
| UniProt ID(s) | P40763 |
| UniGene ID(s) | Hs463059 |
| COSMIC ID Link(s) | STAT3 |
| KEGG Gene ID(s) | hsa:6774 |
| General Description of STAT3 / Signal Transducer and Activator of Transcription 3. | |
| The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. | |
Limitations and Warranty
enQuire Bio’s product, STAT3 / Signal Transducer and Activator of Transcription 3 MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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