Human Anti-STAT6 (Solitary Fibrous Tumor Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-STAT6 (Solitary Fibrous Tumor Marker) Antibody Clone: STAT6/2410
Clone STAT6/2410 Host and Isotype: Mouse IgG1, kappa
Anti-Human STAT6 (Solitary Fibrous Tumor Marker) Positive Control Sample: HeLa or HepG2 cells. Kidney
Cellular Localization of Antibody STAT6/2410 Staining: Cytoplasmic & Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human STAT6 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
STAT6 (Solitary Fibrous Tumor Marker) Previously Observed Antibody Staining Patterns
STAT6 (Solitary Fibrous Tumor Marker) General Information | |
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Alternate Names | |
IL4 STAT; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; STAT interleukin4 induced; STAT6; Transcription factor IL 4 STAT | |
Molecular Weight | |
119kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 6778 |
Entrez Gene ID | STAT6 |
UniProt ID(s) | P42226 |
UniGene ID(s) | Hs524518 |
COSMIC ID Link(s) | STAT6 |
KEGG Gene ID(s) | hsa:6778 |
General Description of STAT6 (Solitary Fibrous Tumor Marker). | |
STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity. |
Limitations and Warranty
enQuire Bio’s product, STAT6 (Solitary Fibrous Tumor Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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