Human Anti-TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody Clone: TPO/1922
Clone TPO/1922 Host and Isotype: Mouse IgG1, kappa
Anti-Human TPO (Thyroid Peroxidase) (Thyroid Marker) Positive Control Sample: Thyroid Carcinoma
Cellular Localization of Antibody TPO/1922 Staining: Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human TPO (apprx. aa 685-804) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
TPO (Thyroid Peroxidase) (Thyroid Marker) Previously Observed Antibody Staining Patterns
TPO (Thyroid Peroxidase) (Thyroid Marker) General Information | |
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Alternate Names | |
MSA; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX | |
Molecular Weight | |
100kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 7173 |
Entrez Gene ID | TPO |
UniProt ID(s) | P07202 |
UniGene ID(s) | Hs467554 |
COSMIC ID Link(s) | TPO |
KEGG Gene ID(s) | hsa:7173 |
General Description of TPO (Thyroid Peroxidase) (Thyroid Marker). | |
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors. |
Limitations and Warranty
enQuire Bio’s product, TPO (Thyroid Peroxidase) (Thyroid Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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