PDF DatasheetHuman, Mouse and Rat Anti-TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Antibody Product Attributes
Species: Human, Mouse and Rat
Tested Applications: IHC.
Clonality: Monoclonal
Anti-TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Antibody Clone: rACP5/1070
Clone rACP5/1070 Host and Isotype: Mouse IgG1
Anti-Human, Mouse and Rat TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Positive Control Sample: HepG2, 293T, K562 or RPMI-8226 Cells. Spleen from Hairy Cell Leukemia (HCL) patient.
Cellular Localization of Antibody rACP5/1070 Staining: Cytoplasmic (Lysosomes)
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human ACP5 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-ACP5 antibody staining is expected to be primarily localized to the cytosol.
| TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) General Information | |
|---|---|
| Alternate Names | |
| Acid phosphatase 5, tartrate resistant; ACP5; serum band 5 tartrate-resistant acid phosphatase; SPENCDI; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR-AP; TRACP5; TRAcP; TRAP; TrATPase; Type 5 acid phosphatase | |
| Molecular Weight | |
| 35kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 54 |
| Entrez Gene ID | ACP5 |
| UniProt ID(s) | P13686 |
| UniGene ID(s) | Hs1211 |
| COSMIC ID Link(s) | ACP5 |
| KEGG Gene ID(s) | hsa:54 |
| General Description of TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker). | |
| It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts. | |
Limitations and Warranty
enQuire Bio’s product, TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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