Human Anti-Tryptase (Mast Cell Marker) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Tryptase (Mast Cell Marker) Antibody Clone: TPSAB1/1961
Clone TPSAB1/1961 Host and Isotype: Mouse IgG1, kappa
Anti-Human Tryptase (Mast Cell Marker) Positive Control Sample: Skin or Tonsil
Cellular Localization of Antibody TPSAB1/1961 Staining: Secreted and Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Tryptase protein fragment (apprx. aa 115-233) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Tryptase (Mast Cell Marker) Previously Observed Antibody Staining Patterns
Tryptase (Mast Cell Marker) General Information | |
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Alternate Names | |
Lung Tryptase; Mast cell alpha II Tryptase; Mast cell beta I Tryptase; Mast cell protease 7; Mast cell protease II; MCP7; Pituitary Tryptase; Skin Tryptase; TPS1; TPSAB1; TPSB1; Tryptase 1; Tryptase alpha 1; Tryptase skin | |
Molecular Weight | |
31-36kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 7177 |
Entrez Gene ID | TPSAB1 |
UniProt ID(s) | Q15661 |
UniGene ID(s) | Hs405479 |
COSMIC ID Link(s) | TPSAB1 |
KEGG Gene ID(s) | hsa:7177 |
General Description of Tryptase (Mast Cell Marker). | |
Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis. |
Limitations and Warranty
enQuire Bio’s product, Tryptase (Mast Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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