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PDF DatasheetHuman Anti-Adiponectin Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Adiponectin Antibody Clone: ADPN/1370
Clone ADPN/1370 Host and Isotype: Mouse IgG2b
Anti-Human Adiponectin Positive Control Sample: HeLa cells or Kidney
Cellular Localization of Antibody Cytoplasmic ;Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Adiponectin protein fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Adiponectin Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Adiponectin expression as measured by anti-Adiponectin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | + | – | – | – | – |
| ADIPOQ Variability | + | ++ | + | + | + | + | ++ | ++ | + | + | + | + | + | + | + | ++ | + | + | ++ | + |
| Adiponectin General Information | |
|---|---|
| Alternate Names | |
| Adiponectin, AdipoQ | |
| Molecular Weight | |
| 26-30kDa | |
| Chromosomal Location | |
| 3q27 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ADIPOQ |
| Entrez Gene ID | 9370 |
| Ensemble Gene ID | ENSG00000181092 |
| RefSeq Protein Accession(s) | NP_004788, NP_001171271 |
| RefSeq mRNA Accession(s) | NM_004797, NM_001177800 |
| RefSeq Genomic Accession(s) | NC_018914, NC_000003, NG_021140 |
| UniProt ID(s) | A8K660, Q15848, B2R773 |
| UniGene ID(s) | A8K660, Q15848, B2R773 |
| HGNC ID(s) | 13633 |
| Cosmic ID(s) | ADIPOQ |
| KEGG Gene ID(s) | hsa:9370 |
| PharmGKB ID(s) | PA134933118 |
| General Description of Adiponectin. | |
| This MAb reacts with adiponectin, an adipocytokine. Adipocytokines are hormones produced in adipose tissue. Adiponectin is abundantly present in plasma and has insulin like effect on glucose levels in the blood. Plasma adiponectin levels are low in insulin resistant patients who are obese, have diabetes mellitus type 2 or HIV-lipodystrophy. In women adiponectin levels tend to be higher than in men, which may be due to androgens suppressing adiponectin levels. Furthermore adiponectin and leptin are both indicated in regulating body weight through direct action on the hypothalamus, influencing appetite. Obese people have low adiponectin levels while levels in anorexia patients are high. Adiponectin acts as ligand for various receptors, two of which have been identified, one probably involved in carbohydrate assimilation, the other in tuning the rate of metabolism. | |
Limitations and Warranty
enQuire Bio’s Adiponectin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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