Human Anti-CD40 / TNFRSF5 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD40 / TNFRSF5 Antibody Clone: C40/1605
Clone C40/1605 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD40 / TNFRSF5 Positive Control Sample: L-428 Cells. Tonsil, Spleen or Thymus
Cellular Localization of Antibody Cell Surface and Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length CD40 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD40 / TNFRSF5 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD40 / TNFRSF5 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen and germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen and germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD40 / TNFRSF5 could be seen inlymphoid tissue in appendix and macrophages in lung. We were unable to detect CD40 / TNFRSF5 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of CD40 / TNFRSF5 expression as measured by anti-CD40 / TNFRSF5 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | - | - | - | - | - | - | - | - | + | - | - | - | - | - | - | - | - | + | - |
| CD40 Variability | + | + | + | + | + | + | + | + | ++ | ++ | + | ++ | + | + | + | + | + | + | ++ | + |
Limitations and Warranty
enQuire Bio's CD40 / TNFRSF5 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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