Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 6 Monoclonal Antibody (KRT6/172)
Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 6 Monoclonal Antibody (KRT6/172)

Anti-Cytokeratin 6 Antibody Clone KRT6/1702

$ 118.00$ 418.00
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SKU: 3853-MSM2
Species: Human and Mouse
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 3853-MSM2-P0
Cytokeratin 6 General Information
Alternate Names
CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E, anti-CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E antibody
Molecular Weight
56kDa
Chromosomal Location
12q13.13 ;12q13.13 ;12q13.13
Curated Database and Bioinformatic Data
Gene SymbolKRT6A ;KRT6B ;KRT6C
Entrez Gene ID3853, 3854, 286887
Ensemble Gene IDENSG00000205420, ENSG00000185479, ENSG00000170465
RefSeq Protein Accession(s)NP_005545, NP_005546, NP_775109
RefSeq mRNA Accession(s)NM_005554, NM_005555, NM_173086,
RefSeq Genomic Accession(s)NG_008298, NC_000012, NC_018923, NG_008299, NC_018923, NC_000012, NC_000012, NC_018923, NG_012416
UniProt ID(s)P02538, A0A0S2Z428, P04259, P48668
UniGene ID(s)P02538, A0A0S2Z428, P04259, P48668
HGNC ID(s)6443, 6444, 20406
Cosmic ID(s)KRT6A, KRT6B, KRT6C
KEGG Gene ID(s)hsa:3853, hsa:3854, hsa:286887
PharmGKB ID(s)PA30231, PA30232, PA134891227
General Description of Cytokeratin 6.
This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Human and Mouse Anti-Cytokeratin 6 Antibody Product Attributes

Species: Human and Mouse
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Cytokeratin 6 Antibody Clone: KRT6/1702
Clone KRT6/1702 Host and Isotype: Mouse IgG2a kappa
Anti-Human and Mouse Cytokeratin 6 Positive Control Sample: Tonsil or basal cell carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length keratin 6 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Cytokeratin 6 Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's Cytokeratin 6 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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