Human Anti-FABP3 / H-FABP Antibody Clone FABP3-Q7

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Species: Human
Tested Applications: ELISA, CLIA
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QDX29-100ug
FABP3 / H-FABP General Information
Alternate Names
FABP3, H-FABP, Mdgi, H-FABP, Fabph-4, Fabph1, Fabph-1, Fabph4, Fatty Acid Binding Protein
Curated Database and Bioinformatic Data
Gene SymbolFABP3
Entrez Gene ID2170
Ensemble Gene IDENSG00000121769
RefSeq Protein Accession(s)NP_001307925, XP_011539309, NP_004093
RefSeq mRNA Accession(s)XM_011541007, NM_001320996, NM_004102,
RefSeq Genomic Accession(s)NG_047049, NC_000001, NC_018912
UniProt ID(s)P05413
UniGene ID(s)P05413
HGNC ID(s)3557
Cosmic ID(s)FABP3
KEGG Gene ID(s)hsa:2170
PharmGKB ID(s)PA27958
General Description of FABP3 / H-FABP.
Heart-type Fatty Acid-Binding Protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. Like the other nine FABPs, H-FABP is involved in active fatty acid metabolism where it transports fatty acids from cell membrane to mitochondria for oxidation.

H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the pain. H-FABP is 20 times more specific to cardiac muscle than myoglobin. It is found at 10-fold lower levels in skeletal muscle than heart muscle and the amounts in the kidney, liver, and small intestine are even lower. H-FABP is recommended to be measured iwth troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest pain. H-FABP measured with troponin shows increased sensitivity of approximately 20% over troponin alone at 3-6 hours following the onset of chest pain.

H-FABP also has prognostic value. Alongside D-dimer NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically significant predictor of death or recurrent MI at one year. This prognostic information was independent of other markers.

Human Anti-FABP3 / H-FABP Antibody Product Attributes

Species: Human
Tested Applications: ELISA, CLIA.
Clonality: Monoclonal
Anti-FABP3 / H-FABP Antibody Clone: FABP3-Q7
Clone FABP3-Q7 Host and Isotype: Mouse IgG1
Buffer and Stabilizer: PBS (pH 7.4)
Antibody Purification Method:Protein G
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.

FABP3 / H-FABP Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-FABP3 antibody staining is expected to be primarily localized to the golgi apparatus.

Observed Antibody Staining Data By Tissue Type:

Variations in FABP3 / H-FABP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of FABP3 / H-FABP could be seen inmyocytes in skeletal muscle. We were unable to detect FABP3 / H-FABP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Anti-Human FABP3 / H-FABP Antibody is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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