Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody (TV-1).
Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody (TV-1).

Anti-Fibronectin Antibody Clone TV-1

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2335-MSM2
Species: Human, Pig, Mouse, and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2335-MSM2-P1
Fibronectin General Information
Alternate Names
Fibronectin, FN1
Molecular Weight
220kDa (monomer); 440kDa (dimer)
Chromosomal Location
2q35
Curated Database and Bioinformatic Data
Gene SymbolFN1
Entrez Gene ID2335
Ensemble Gene IDENSG00000115414
RefSeq Protein Accession(s)XP_005246460, XP_005246464, XP_005246473, NP_997641, XP_005246461, XP_005246467, XP_005246469, XP_016859183, NP_001293060, NP_997639, NP_997647, XP_005246454, XP_005246466, XP_005246471, XP_016859182, NP_001293059, XP_005246458, XP_016859181, NP_001293058, XP_005246465, XP_005246468, NP_473375, XP_005246455, XP_005246459, NP_002017, NP_997643, XP_005246462, XP_005246456, XP_005246463, XP_016859184, NP_001293061
RefSeq mRNA Accession(s)XM_005246416, XM_017003692 NM_212476, XM_005246407, XM_005246410, XM_005246414, XM_017003694, NM_001306129, NM_001306130, NM_212474, XM_005246402, XM_005246408, XM_005246409, XM_005246399, NM_001306131, NM_054034, XM_005246403, XM_005246405, XM_005246406, XM_017003695, NM_002026, XM_005246398, XM_005246401, XM_005246404, XM_005246412, XM_017003693, NM_001306132, XM_005246397, XM_005246411, NM_212478, NM_212482, NM_212475
RefSeq Genomic Accession(s)NC_000002, NG_012196, NC_018913
UniProt ID(s)Q6N084, Q9UQS6, B7ZLE5, Q6MZF4, Q6MZM7, P02751
UniGene ID(s)Q6N084, Q9UQS6, B7ZLE5, Q6MZF4, Q6MZM7, P02751
HGNC ID(s)3778
Cosmic ID(s)FN1
KEGG Gene ID(s)hsa:2335
PharmGKB ID(s)PA28194
General Description of Fibronectin.
Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix,, blood. This MAb reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this MAb localizes to tumor vessels where it binds to the underlying basement. Epitope recognized by this antibody is not accessible in normal tissues to the circulating MAb indicating that it can be used to specifically target tumor vessels in vivo. TV-1 is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or MAbs.

Human, Pig, Mouse, and Rat Anti-Fibronectin Antibody Product Attributes

Species: Human, Pig, Mouse, and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Fibronectin Antibody Clone: TV-1
Clone TV-1 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Pig, Mouse, and Rat Fibronectin Positive Control Sample: SW156 cells or Kidney
Cellular Localization of Antibody Connective tissue matrix
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: T-cell lymphoma biopsy
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Fibronectin Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Fibronectin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney. More moderate antibody staining intensity was present in cells in the tubules in kidney. Low, but measureable presence of Fibronectin could be seen inadipocytes in breast, cells in the endometrial stroma in endometrium, cells in the molecular layer in cerebellum, cells in the red pulp in spleen, cells in the seminiferous ducts in testis, cells in the white pulp in spleen, glandular cells in the appendix, breast, epididymis, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, glial cells in the caudate nucleus, hematopoietic cells in the bone marrow, hepatocytes in liver, macrophages in lung, neuronal cells in the hippocampus, peripheral nerve in mesenchymal tissue, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the esophagus and oral mucosa, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect Fibronectin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Fibronectin expression as measured by anti-Fibronectin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - + - - - ++ + - - - ++ - - - - + ++ +
FN1 Variability ++ ++ ++ +++ ++ + ++ +++ ++ + ++ ++ +++ + + + ++ ++ ++ +++

Limitations and Warranty

enQuire Bio's Fibronectin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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