Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with PSAP Monoclonal Antibody (SPM312).
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with PSAP Monoclonal Antibody (SPM312).

Anti-PSAP Antibody Clone SPM312

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 55-MSM3X
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
55-MSM3X-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
55-MSM3X-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
55-MSM3X-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
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SKU: 55-MSM3X-P0
PSAP General Information
Alternate Names
Prostatic acid phosphatase, PAP, prostatic specific acid phosphatase, PSAP
Molecular Weight
52kDa
Chromosomal Location
3q22.1
Curated Database and Bioinformatic Data
Gene SymbolACPP
Entrez Gene ID55
Ensemble Gene IDENSG00000014257
RefSeq Protein Accession(s)XP_011511248, NP_001090, NP_001278966, XP_011511249, NP_001127666
RefSeq mRNA Accession(s)XM_011512946, NM_001134194, XM_011512947, NM_001292037 NM_001099
RefSeq Genomic Accession(s)NC_000003, NC_018914, NG_047032
UniProt ID(s)P15309
UniGene ID(s)P15309
HGNC ID(s)125
Cosmic ID(s)ACPP
KEGG Gene ID(s)hsa:55
PharmGKB ID(s)PA24449
General Description of PSAP.
Recognizes a protein of 52kDa, identified as prostate specific acid phosphatase (PSAP). This enzyme catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. PSAP is found in non-neoplastic adult and fetal prostatic glands, primary and metastatic prostatic carcinomas. It shows no staining in granulocytes, osteoclasts, parietal cells of the stomach, liver cells, renal cell or breast carcinomas.

Human Anti-PSAP Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-PSAP Antibody Clone: SPM312
Clone SPM312 Host and Isotype: Mouse IgG1 kappa
Anti-Human PSAP Positive Control Sample: PC12 cells or normal prostate or prostate carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Prostatic acid phosphatase purified from human seminal plasma
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

PSAP Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in PSAP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the prostate. More moderate antibody staining intensity was present in glandular cells in the prostate. Low, but measureable presence of PSAP could be seen in. We were unable to detect PSAP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of PSAP expression as measured by anti-PSAP antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - +++ - - - - - -
ACPP Variability + + + + + + + + + + + + + + + + + + + +

Limitations and Warranty

enQuire Bio's PSAP Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-PSAP Antibody Clone SPM312

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