Analysis of Protein Array containing >19,000 full-length human proteins using Kappa Light Chain Recombinant Mouse Monoclonal Antibody (rKLC709) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing >19,000 full-length human proteins using Kappa Light Chain Recombinant Mouse Monoclonal Antibody (rKLC709) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis of Purified Kappa Light Chain Mouse Recombinant Monoclonal Ab (rKLC709).Confirmation of Purity and Integrity of Antibody.

Kappa Light Chain / IGKC (B-Cell Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3514-MSM10
Species: Human
Tested Applications: Flow, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
3514-MSM10-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
3514-MSM10-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
3514-MSM10-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
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SKU: 3514-MSM10-P0
Kappa Light Chain / IGKC (B-Cell Marker) General Information
Alternate Names
HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM
Molecular Weight
~22.5kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol3514
Entrez Gene IDIGKC
UniProt ID(s)P01601 & P01834
UniGene ID(s)Hs449609
COSMIC ID Link(s)IGKC
KEGG Gene ID(s)hsa:3514
General Description of Kappa Light Chain / IGKC (B-Cell Marker).
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Human Anti-Kappa Light Chain / IGKC (B-Cell Marker) Antibody Product Attributes

Species: Human
Tested Applications: Flow, IHC.
Clonality: Monoclonal
Anti-Kappa Light Chain / IGKC (B-Cell Marker) Antibody Clone: rKLC709
Clone rKLC709 Host and Isotype: Mouse IgG1, kappa
Anti-Human Kappa Light Chain / IGKC (B-Cell Marker) Positive Control Sample: 293T, Raji or hPBL cells. Tonsil or Spleen
Cellular Localization of Antibody rKLC709 Staining: Cell Surface, cytoplasmic and secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human Ig kappa chain
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Kappa Light Chain / IGKC (B-Cell Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Kappa Light Chain / IGKC (B-Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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Kappa Light Chain / IGKC (B-Cell Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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