PDF DatasheetHuman Anti-Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Antibody Clone: SOD1/2089
Clone SOD1/2089 Host and Isotype: Mouse IgG
Anti-Human Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Positive Control Sample: HeLa or Jurkat Cells. Breast or Ovarian carcinoma
Cellular Localization of Antibody SOD1/2089 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human SOD1 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Previously Observed Antibody Staining Patterns
| Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) General Information | |
|---|---|
| Alternate Names | |
| Amyotrophic lateral sclerosis 1 (ALS1); Cu/Zn SOD; Cu/Zn Superoxide Dismutase; Epididymis Secretory Protein Li 44; Indophenoloxidase A (IPOA); Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1 (SOD1) | |
| Molecular Weight | |
| 23kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 6647 |
| Entrez Gene ID | SOD1 |
| UniProt ID(s) | P00441 |
| UniGene ID(s) | Hs443914 |
| COSMIC ID Link(s) | SOD1 |
| KEGG Gene ID(s) | hsa:6647 |
| General Description of Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme). | |
| Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death. | |
Limitations and Warranty
enQuire Bio’s product, Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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