PDF DatasheetHuman Ras-related protein Rab-8A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras-related protein Rab-8A based upon sequence from Human
Host: QP6575 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras-related protein Rab-8A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6575.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Lys3 – Pro193
Amino Acid Sequence: KTYDYLFKLL LIGDSGVGKT CVLFRFSEDA FNSTFISTIG IDFKIRTIEL DGKRIKLQIW DTAGQERFRT ITTAYYRGAM GIMLVYDITN EKSFDNIRNW IRNIEEHASA DVEKMILGNK CDVNDKRQVS KERGEKLALD YGIKFMETSA KANINVENAF FTLARDIKAK MDKKLEGNSP QGSNQGVKIT P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ras-related protein Rab-8A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras-related protein Rab-8A Protein General Information | |
|---|---|
| Alternate Names | |
| RAB8, MEL | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAB8A |
| Entrez Gene ID | 4218 |
| Ensemble Gene ID | ENSG00000167461 |
| RefSeq Protein Accession(s) | NP_005361.2 |
| RefSeq mRNA Accession(s) | NM_005370.4 |
| UniProt ID(s) | P61006 |
| UniGene ID(s) | Hs.642874 |
| HGNC ID(s) | HGNC:7007 |
| COSMIC ID Link(s) | RAB8A |
| KEGG Gene ID(s) | hsa:4218 |
| PharmGKB ID(s) | PA30743 |
| General Description of Recombinant Human Ras-related protein Rab-8A Protein. | |
| The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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