PDF DatasheetHuman Ras-related GTP-binding protein A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras-related GTP-binding protein A based upon sequence from: Human
Host: QP8446 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras-related GTP-binding protein A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8446.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ala247
Amino Acid Sequence: MPNTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATIDVEHSHV RFLGNLVLNL WDCGGQDTFM ENYFTSQRDN IFRNVEVLIY VFDVESRELE KDMHYYQSCL EAILQNSPDA KIFCLVHKMD LVQEDQRDLI FKEREEDLRR LSRPLECACF RTSIWDETLY KAWSSIVYQL IPNVQQLEMN LRNFAQIIEA DEVLLFERAT FLVISHYQCK EQRDVHRFEK ISNIIKQFKL SCSKLAA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ras-related GTP-binding protein A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras-related GTP-binding protein A Protein General Information | |
|---|---|
| Alternate Names | |
| FIP1; FIP-1; RAGA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAGA |
| Entrez Gene ID | 10670 |
| Ensemble Gene ID | ENSG00000155876 |
| RefSeq Protein Accession(s) | NP_006561.1 |
| RefSeq mRNA Accession(s) | NM_006570.4 |
| UniProt ID(s) | Q7L523 |
| UniGene ID(s) | Hs.743260 |
| HGNC ID(s) | HGNC:16963 |
| KEGG Gene ID(s) | hsa:10670 |
| PharmGKB ID(s) | PA134980509 |
| General Description of Recombinant Human Ras-related GTP-binding protein A Protein. | |
| Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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