PDF DatasheetHuman 3-hydroxyacyl-CoA dehydrogenase type-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant 3-hydroxyacyl-CoA dehydrogenase type-2 based upon sequence from: Human
Host: QP8037 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) 3-hydroxyacyl-CoA dehydrogenase type-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8037.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Pro261
Amino Acid Sequence: AAACRSVKGL VAVITGGASG LGLATAERLV GQGASAVLLD LPNSGGEAQA KKLGNNCVFA PADVTSEKDV QTALALAKGK FGRVDVAVNC AGIAVASKTY NLKKGQTHTL EDFQRVLDVN LMGTFNVIRL VAGEMGQNEP DQGGQRGVII NTASVAAFEG QVGQAAYSAS KGGIVGMTLP IARDLAPIGI RVMTIAPGLF GTPLLTSLPE KVCNFLASQV PFPSRLGDPA EYAHLVQAII ENPFLNGEVI RLDGAIRMQP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human 3-hydroxyacyl-CoA dehydrogenase type-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 Protein General Information | |
|---|---|
| Alternate Names | |
| ABAD; HCD2; SCHAD; CAMR; DUPXp11.22; MHBD; MRX17; MRPP2; MRX31; MRXS10; SDR5C1; HADH2; 17b-HSD10; ERAB | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HSD17B10 |
| Entrez Gene ID | 3028 |
| Ensemble Gene ID | ENSG00000072506 |
| RefSeq Protein Accession(s) | NP_001032900.1 |
| RefSeq mRNA Accession(s) | NM_001037811.2, NM_004493.2 |
| UniProt ID(s) | Q99714 |
| UniGene ID(s) | Hs.171280 |
| HGNC ID(s) | HGNC:4800 |
| COSMIC ID Link(s) | HSD17B10 |
| KEGG Gene ID(s) | hsa:3028 |
| PharmGKB ID(s) | PA162391638 |
| General Description of Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 Protein. | |
| Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5′-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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