PDF DatasheetHuman Ras association domain-containing protein 5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras association domain-containing protein 5 based upon sequence from: Human
Isoform: Isoform 2
Host: QP7834 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras association domain-containing protein 5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7834.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Gly265
Amino Acid Sequence: MTVDSSMSSG YCSLDEELED CFFTAKTTFF RNAQSKHLSK NVCKPVEETQ RPPTLQEIKQ KIDSYNTREK NCLGMKLSED GTYTGFIKVH LKLRRPVTVP AGIRPQSIYD AIKEVNLAAT TDKRTSFYLP LDAIKQLHIS STTTVSEVIQ GLLKKFMVVD NPQKFALFKR IHKDGQVLFQ KLSIADRPLY LRLLAGPDTE VLSFVLKENE TGEVEWDAFS IPELQNFLTI LEKEEQDKIQ QVQKKYDKFR QKLEEALRES QGKPG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ras association domain-containing protein 5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras association domain-containing protein 5 Protein General Information | |
|---|---|
| Alternate Names | |
| Maxp1; RASSF3; NORE1A; RAPL; NORE1; NORE1B | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RASSF5 |
| Entrez Gene ID | 83593 |
| Ensemble Gene ID | ENSG00000266094 |
| RefSeq Protein Accession(s) | NP_872604.1 |
| RefSeq mRNA Accession(s) | NM_182663.3, NM_182664.3, NM_182665.3 |
| UniProt ID(s) | Q8WWW0 |
| UniGene ID(s) | Hs.497579 |
| HGNC ID(s) | HGNC:17609 |
| COSMIC ID Link(s) | RASSF5 |
| KEGG Gene ID(s) | hsa:83593 |
| PharmGKB ID(s) | PA134958571 |
| General Description of Recombinant Human Ras association domain-containing protein 5 Protein. | |
| Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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