PDF DatasheetHuman Suppressor of cytokine signaling 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Suppressor of cytokine signaling 2 based upon sequence from Human
Host: QP6712 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Suppressor of cytokine signaling 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6712.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG LPLPTRLKDY LEEYKFQV
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Suppressor of cytokine signaling 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Suppressor of cytokine signaling 2 Protein General Information | |
|---|---|
| Alternate Names | |
| SOCS-2, Cish2, SSI2, STATI2, SSI-2, CIS2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SOCS2 |
| Entrez Gene ID | 8835 |
| Ensemble Gene ID | ENSG00000120833 |
| RefSeq Protein Accession(s) | NP_001257396.1 |
| RefSeq mRNA Accession(s) | NM_001270467.1, NM_001270468.1, NM_001270469.1, NM_001270470.1, NM_001270471.1, NM_003877.4, XM_017020156.1 |
| UniProt ID(s) | O14508 |
| UniGene ID(s) | Hs.485572 |
| HGNC ID(s) | HGNC:19382 |
| COSMIC ID Link(s) | SOCS2 |
| KEGG Gene ID(s) | hsa:8835 |
| PharmGKB ID(s) | PA128394542 |
| General Description of Recombinant Human Suppressor of cytokine signaling 2 Protein. | |
| SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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