PDF DatasheetMouse Anti-Anti-CD152 Antibody Product Attributes
Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-Anti-CD152 Antibody Clone: UC10-4F10-11
Clone UC10-4F10-11 Host and Isotype: Armenian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.2 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.
Anti-CD152 Previously Observed Antibody Staining Patterns
| Anti-CD152 General Information | |
|---|---|
| Alternate Names | |
| CTLA4, CD152, CTLA-4, ALPS5, GRD4, CD, CD152, IDDM12, GSE, CELIAC3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Ctla4 |
| Entrez Gene ID | 12477 |
| Ensemble Gene ID | ENSMUSG00000026011, ENSMUSG00000103326 |
| RefSeq Protein Accession(s) | NP_033973, NP_001268905 |
| RefSeq mRNA Accession(s) | NM_001281976, NM_009843 |
| RefSeq Genomic Accession(s) | NW_006763128, NG_187019, NC_000067 |
| UniProt ID(s) | Q5SSM0, P09793, Q6GTR6 |
| UniGene ID(s) | Q5SSM0, P09793, Q6GTR6 |
| Cosmic ID(s) | Ctla4 |
| KEGG Gene ID(s) | mmu:12477 |
| General Description of Anti-CD152. | |
| The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression. | |
Selected References
Lischke T, Hegemann A, Gurka S, Van DV, Burmeister Y, Lam K-P, Kershaw O, Mollenkopf H-J, Mages HW, Hutloff A, and Kroczek RA. 2012. J. Immunol. 189: 234-244. (Flow Cytometry). Tai X, Laethem FV, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, and Singer A. 2012. 119: 5155-5163. (Flow Cytometry). Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, and Calahan MD. 2012. 109: E1258-E1266. (in vitro blocking).
Limitations and Warranty
enQuire Bio’s Mouse Anti-CD152 / CTLA-4 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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