PDF DatasheetHuman Anti-CD10 / Neprilysin / MME Antibody Product Attributes
CD10 / Neprilysin / MME Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD10 / Neprilysin / MME antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney, cells in the tubules in kidney and glandular cells in the duodenum, prostate and small intestine. More moderate antibody staining intensity was present in cells in the glomeruli in kidney, cells in the tubules in kidney and glandular cells in the duodenum, prostate and small intestine. Low, but measureable presence of CD10 / Neprilysin / MME could be seen inmacrophages in lung. We were unable to detect CD10 / Neprilysin / MME in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD10 / Neprilysin / MME General Information | |
|---|---|
| Alternate Names | |
| CD1, Neprilysin, MME, C85356, SFE, NEP, CD1, 63454K5Rik, CALLA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MME |
| Entrez Gene ID | 4311 |
| Ensemble Gene ID | ENSG00000196549 |
| RefSeq Protein Accession(s) | XP_006713710, NP_001341571, XP_011511157, NP_009218, NP_009220, XP_011511159, NP_000893, NP_001341573, XP_006713709, XP_011511158, NP_001341572, NP_009219 |
| RefSeq mRNA Accession(s) | XM_006713647, NM_001354642, NM_001354643, NM_007289, XM_011512856 NM_007287, XM_006713646, NM_007288, XM_011512855, XM_011512857, NM_000902, NM_001354644 |
| RefSeq Genomic Accession(s) | NG_051105, NC_000003, NC_018914 |
| UniProt ID(s) | P08473 |
| UniGene ID(s) | P08473 |
| HGNC ID(s) | 7154 |
| Cosmic ID(s) | MME |
| KEGG Gene ID(s) | hsa:4311 |
| PharmGKB ID(s) | PA30864 |
| General Description of CD10 / Neprilysin / MME. | |
| The SN5c antibody is specific for human CD10, a 100 kDa type II transmembrane protein also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). In normal cells, it is expressed on early B and T lymphoid precursors, neutrophils and on various epithelia. CD10 is also expressed on several lymphoma cells including Burkitts, acute lymphoblastic, and follicular germinal center lymphomas. CD10 functions as an endopeptidase and is involved in B cell development, as well as a mediator of neutrophil inflammatory responses. | |
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